ISIS Report 06/10/08

GM is Dangerous and Futile

We Need Organic Sustainable Food and Energy Systems Now

New genetics research invalidates the science underpinning the $73.5 billon global biotech industry and confirms why genetic modification is futile and dangerous; we must implement organic sustainable food and energy systems now Dr. Mae-Wan Ho

Invited Lecture at Conference on Future of Food: Climate Change, GMOs and Food Security, 1-2 October 2008, India International Centre, New Delhi

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I am deeply and doubly honoured to be part of this important conference on Mahatma Gandhi’s birthday, because it was Vandana Shiva and Tewolde Berhan Gebre Egziabher who inspired me and turned me from an ivory tower academic into a science activist. Consequently, I was thrown out of my university and liberated to join civil society in fighting corrupt science and protecting good independent science.

“Change to gene theory raises new challenges for biotech”

The headline appeared in the business section of the International Herald Tribune 3 July 2007 [1]. The article went on to say: “The $73.5 billion global biotech business may soon have to grapple with a discovery that calls into question the scientific principles on which it was founded.”

It was referring to the findings of project ENCODE (Encyclopedia of DNA elements), organised by the US National Human Genome Research Institute. A consortium of 35 research groups went through 1 percent of the human genome with a fine-tooth comb to find out exactly how genes work.

To their surprise, researchers found that the human genome might not be a “tidy collection of independent genes” after all…Instead, genes appear to operate in a complex network, and interact and overlap with one another and with other components in ways not yet fully understood.”

The Human Genome Research Institute said that these findings will challenge scientists “to rethink some long-held views about what genes are and what they do.”

The author of the article Denis Caruso commented that, “the report is likely to have repercussions far beyond the laboratory. The presumption that genes operate independently has been institutionalized since 1976, when the first biotech company was founded. In fact, it is the economic and regulatory foundation on which the entire biotechnology industry is built.” She went on to point out that gene patents and safety assessment based on the same paradigm are also in trouble.

She is right on all counts. I pointed that out 10 years previously when a plethora of findings in molecular genetics had already invalidated the genetic determinist paradigm underpinning the biotech industry. In fact, the paradigm had begun to unravel almost as the industry was starting up twenty years earlier.

The Brave New World of GM Science

In Genetic Engineering Dream or Nightmare, the Brave New World of Bad Science and Big Business [2] first published in 1997/1998 I explained why the science behind GM is wrong and obsolete, and hence dangerous; a story elaborated further in Living with the Fluid Genome [3] published in 2003.

Genetic engineering of plants and animals began in the mid 1970s in the belief that the genome (the totality of all the genetic material of a species) is constant and static, and that the characteristics of organism are simply hardwired in their genome. This was encapsulated in the Central Dogma of molecular biology. The genetic information goes from DNA, the genetic material, to RNA, a kind of intermediate, to protein which determines the characteristic involved, such as tolerance to herbicide, for example. One gene determines one trait, so you can transfer one gene and get exactly the trait you want, be it herbicide tolerance, or resistance to insect pest.

But geneticists soon discovered that the genome is remarkably dynamic and ‘fluid’. It is constantly in conversation with the environment, and that determines which genes are turned on, when, where, by how much and for how long. Moreover, the genetic material itself could also be marked or changed according to experience, and the influence passed on to the next generation. Most of that was known by 1980, long before the Human Genome Project was conceived.

The best thing about the Human Genome Project is to finally explode the myth of genetic determinism [4] (The Myth that Launched a Thousand Companies, SiS 18), revealing the layers of molecular complexity that transmit, interpret and rewrite the genetic texts [5] (Life Beyond the Central Dogma series, SiS 24). The ENCODE project has confirmed and extended the complexities especially with regard to what constitutes a gene. Traditionally, a gene is a sequence of DNA that codes for a protein with a well-defined function. This idea has been well and truly shattered [6]; as Barry Patrick wrote in the Science News [7] “genes are proving to be fragmented, intertwined with other genes, and scattered across the whole genome.”

The genetic engineer’s idea of a gene is presented in Figure 1. It has a regulatory signal, a promoter that says to the cell, go and make lots of copies of the coding sequence that would be translated into a protein, and a terminator that says stop, end of message. This is what genetic engineers put into cells to make a genetically modified organism (GMO).

Figure 1.  A gene expression cassette, the genetic engineer’s idea of a gene

Instead, within the human genome, and indeed other mammalian genomes, coding sequences are in bits (exons) separated by non-coding introns, and exons contributing to a single protein could be in different parts of the genome. Coding sequences of different proteins frequently overlap. Regulatory signals are similarly scattered upstream, downstream, within the coding sequence or in some other distant part of the genome. Coding sequences occupy just 1.5 percent of the human genome, but between 74 and 93 percent of the genome produce RNA transcripts [7], many now known to have regulatory functions. So much so that the project of mapping genetic predisposition to diseases, the original rationale for the Human Genome Project, has now run into serious trouble.

David M. Altshuler, associate professor of genetics and medicine at Harvard Medical School and his research team showed that the risk for type 2 diabetes involves more than a mutated gene. Instead, diabetes, heart disease, some cancers, and other deadly ailments involve non-coding DNA as well as in genes [8]. “We’re realizing that things happening ‘somewhere else’ in the genome, not in genes, are playing critical roles” in sickness and in health, Altshuler said.

David B. Goldstein at Duke University is very pessimistic. He said the effort to nail down the genetics of most common diseases is not working [9]: “There is absolutely no question that for the whole hope of personalized medicine, the news has been just as bleak as it could be. After doing comprehensive studies for common diseases, we can explain only a few percent of the genetic components of most of these traits.” For schizophrenia and biopolar disorder, there is almost nothing, for type 2 diabetes, 20 variants, but they explain only up to 3 percent of familial clustering, and so on.

Goldstein added: “we have cracked open the human genome and can look at the entire complement of common genetic variants, and what do we find? Almost nothing. That is absolutely beyond belief.”

That is just what I predicted soon after the human genome sequence was announced [10, 11] (Human DNA 'BioBank' Worthless, SiS 13/14; Why Genomics Won't Deliver, SiS 26)

Fresh attempts are now made to redefine a gene either in terms of a protein product [12] or a transcript [13], neither of which are satisfactory or would save the industry. All patents on genes based on the old concept are no longer valid; ultimately because the patent is awarded on a supposed function attached to a DNA sequence. But as genes exist in bits interweaving with other genes, so are functions. Multiple DNA sequences may serve the same function, and conversely the same DNA sequence can have different functions. Again, I have explained Why Biotech Patents Are Patently Absurd [14].

Despite the bewildering complexities of how the genome works, individual processes are precisely orchestrated and finely tuned by the organism as a whole, in a highly coordinated molecular ‘dance of life’ that’s necessary for survival.

In contrast, genetic engineering in the laboratory is crude, imprecise and invasive. The rogue genes inserted into a genome to make a GMO could land anywhere; typically in a rearranged or defective form, scrambling and mutating the host genome, and tend to move or rearrange further once inserted. Transgene instability is a big problem, and has been so right from the beginning. There is fresh evidence that GM crops grown commercially for years have rearranged [15, 16] (MON810 Genome Rearranged Again. Transgenic Lines Unstable hence Illegal and Ineligible for Protection, SiS 38). This is a real opportunity to challenge the validity of all biotech patents. Another key issue is safety. Transgene instability means that the original transgenic line has turned into something else, and even if it had been assessed as ‘safe’, this is no longer the case.

The genetically modified genes are a big hazard because they do not know the intricate dance of life that has been perfected in billions of years of evolution. That’s ultimately why genetic modification is both dangerous and futile.

Thirty years of GM are more than enough

We’d had 30 years of GM and more than enough damage done, as detailed in the ISP Report The Case for A GM-Free Sustainable World [17] and the dossier GM Science Expose : Hazards Ignored, Fraud, Regulatory Sham, Violation of Farmers Rights [18] we compiled for the European Parliament in June 2007. And more evidence has been piling up since. Why has this been allowed to go on? W documented how national and international regulators and advisory bodies such as the European Food Safety Authority not only routinely ignore the precautionary principle, but also actively abuse science, sidestep the law, and helping to promote GM technology in the face of evidence piling up against the safety of GM food and feed [19] (GM Food Nightmare Unfolding in the Regulatory Sham, ISIS scientific publication).

Let me summarize the evidence stacked up against GMOs.

• No increase in yields

Successive reports [17, 18, 20] confirm that the yields of all major GM crops varieties cultivated are lower than, or at best, equal to yields from non-GM varieties. Studies from 1999 to 2007 consistently show that GM soya decreased yields by 4 to 12 percent compared to non-GM soya, while Bt maize yields from 0 to 12 percent less than conventional isolines. Up to 100 percent failures of Bt cotton crops have been recorded in India [18] (and amply confirmed by the farmer witnesses who are here today). New research from the University of Kansas found a 10 percent average yield drag for Roundup Ready soya [21], and extra manganese is needed for the soil  Scientists from the USDA and the University of Georgia found growing GM cotton in the US could result in a drop in income by up to 40 percent [22, 23] (Transgenic Cotton Offers No Advantage, SiS 38) 

• No reduction in pesticides use

USDA data showed that GM crops increase pesticide use by 50 million pounds from 1996 to 2003 in the United States [17]. New data paint an even grimmer picture: the use of glyphosate on major crops went up more than 15-fold between 1994 and 2005, along with increases in other herbicides [24] in order to cope with rising glyphosate resistant superweeds [6]. Palmer 3pigweed is a major concern in Georgia, with farmer there having to mow cotton down in fields with glyphosate-resistant Palmer amaranth [25]. And following close on the health of that is glyphosate resistant giant ragweed [26]. Roundup tolerant canola volunteers are top among the worries of Canadian farmers [27, 28] (Study Based on Farmers’ Experience Exposes Risks of GM Crops, SiS 38)

• Roundup lethal to frogs and toxic to human placental and embryonic cells [18].

Roundup is more toxic than glyphosate, and it is used in more than 80 percent of all GM crops planted in the world.

• GM crops harm wildlife

UK’s farm scale evaluations have found that GM crops harm wildlife [18]; more recently a study led by Loyola University, Chicago, Illinois in the United Stated, found that wastes from Bt corn impaired the growth of a common aquatic insect [29, 30] (Bt Crops Threaten Aquatic Ecosystems, SiS 36). This is just the tip of the iceberg. There is evidence that GM crops, especially Bt crops contribute to the demise of the honeybee worldwide because it compromises their immune system and make them exra-susceptible to attacks by parasitic fungus (31) (Parasitic Fungi and Pesticides Act Synergistically to Kill Honeybees? SiS 35).

• Bt resistance pests and Roundup tolerant superweeds render the two major GM crop traits practically useless [18].

A recent review concluded that [32] “evolved glyphosate-resistant weeds are a major risk for the continued success of glyphosate and transgenic glyphosate-resistant crops.” And the evolution of Bt resistant bollworms worldwide have now been confirmed and documented in more than a dozen fields in Mississippi and Arkansas between 2003 and 2006 [33]. Worse yet, secondary pests now plague the fields and spread to other crops in India [34] (Deadly gift from Monsanto to India, SiS 38).

• Vast areas of forests, pampas and cerrados lost to GM soya in Latin America

Argentina alone has lot 15 m hectares [18]; and this has worsened considerably with the demand for biofuels (see later)

• Epidemic of suicides in the cotton belt of India

An estimated 100 000 farmers have killed themselves between 1993-2003, and a further 16 000 farmers a year have died since Bt cotton was introduced [18]

• GM food and feed linked to deaths and sicknesses

Evidence of serious health impacts in lab tests and from farmers’ fields around the world (more below)

GM food and feed inherently hazardous to health [19]

Here are some highlights from our GM Science dossier [18] on the hazards of GM food and feed. Dr. Irina Ermakova of the Russian Academy of Sciences showed how GM soya made female rats give birth to severely stunted and abnormal litters, with more than half dying in three weeks, and those remaining are sterile. Hundreds of villagers and cotton handlers in India suffer allergy-like symptoms, thousands of sheep died after grazing on the Bt cotton residues, goat and cows as well were reported in 2007 and 2008 [35] (Mass Protests against GM Crops in India , SiS 38). (As reported by farmer witnesses as this conference, the problem is continuing and sterility in offspring of exposed animals has also been observed.) A harmless bean protein transferred to pea when tested on mice cause severe inflammation in the lungs and provoked generalised food sensitivities. Dozens of villagers in the south of the Philippines fell ill when neighbouring GM maize fields came into flower in 2003, at least five have died and some remain ill to this day. A dozen cows died having eaten GM maize in Hesse Germany and more in the herd had to be slaughtered from mysterious illnesses. Arpad Pusztai and his colleagues in the UK found GM potatoes with snowdrop lectin damaged every organ system of young rats; the stomach lining grew twice as thick as controls. Chickens fed GM maize Chardon LL were twice as likely to die as controls. And finally, GM maize Mon 863 was claimed to be as safe as non-GM maize by the company, and accepted as such by European Food Safety Authority. But independent scientists of CriiGen in France re-analysed the data and found signs of liver and kidney toxicity.

Different animals and human beings exposed to a variety of transgenic crops with different traits either fall ill or die. The evidence compels us to consider the possibility that the hazards of GMOs may be inherent to the technology, as I suggested more than ten years ago [2].

An epidemic of Morgellons Disease has hit the US and other countries that had been involved in genetic modification technology [36] (Agrobacterium & Morgellons Disease, A GM Connection?. SiS 38). The pathogen is suspected to be Agrobacterium, which has been widely used in smuggling genes into cells to make GMOs. Is this a disease created by GM? There have been close calls before.

US courts rule GM crop field-tests and releases illegal

The message that GM crops are unsafe appears to have got through to the judiciary system in the United States. There have been three court rulings against the US Department of Agriculture (USDA) for failing to carry out proper environmental impact assessment, making the original releases illegal [37] (Approval of GM Crops Illegal, US Federal Courts Rule, SiS 34). These are the first rulings against GMOs in the top producing country in the world, which has been also promoting GMOs aggressively.

The first case was on drug-producing GM crops in Hawaii. The court said that the USDA violated the Endangered Species Act as well as the National Environmental Policy Act.

The second court case not only ruled GM herbicide-tolerant creeping bentgrass illegal, but also that the USDA must halt approval of all new field trials until more rigorous environmental reviews are conducted.

The third decision was passed on Monsanto’s Roundup Ready alfalfa for having been commercial released illegally without an Environment Impact Statement.

An avalanche of bans and rulings strikes GM crops worldwide

There have been numerous bans and restrictions imposed on GM crops in recent years, which say a lot about the inadequacies of regulatory regimes worldwide (see Box 1).

EU Commissioner for the Environment Stavros Dimas has expressed serious reservations concerning GMOs [53] (GM-Free Europe Beginning?, SiS 36), which is unprecedented in the history of the European Commission. On 7 May 2008, the European Commission delayed a decision on allowing farmers to grow more GM crops, and asked European Food Safety Authority to reconsider its previous review, which it had admitted was inadequate, as it was unable to take indirect and long term impacts into account [54].

No case for GM crops, small scale organic farming is the way ahead

Meanwhile, on 15 April 2008, 400 scientists of the International Assessment of Agricultural Science and Technology for Development (IAASTD) released its 2 500-page report [55, 56] (GM-Free Organic Agriculture to Feed the World”, SiS 38) that took 4 years to complete. It is a thorough examination of global agriculture on a scale comparable to the Intergovernment Panel on Climate Change.

The IAASTD calls for a fundamental change in farming practice to counteract soaring food prices, hunger, poverty and environmental disasters, it says GM crops are controversial with respect to safety for health and the environment, and will not play a substantial role in addressing climate change, loss of biodiversity, hunger and poverty. Small scale farmers and agro-ecological methods are the way forward, and indigenous and local knowledge are as important as formal scientific knowledge. It warns that growing crops for biofuels could worsen food shortages and price rises.

The conclusions of the IAASTD are remarkably similar to our own report Food Futures Now *Organic *Sustainable *Fossil Fuel Free  [57] launched in UK Parliament a week later.

Our Food Futures Now report goes a step further. We argue that only organic agriculture can truly feed the world. More than that, organic agriculture and localised food and energy systems can potentially compensate for all greenhouse emissions due to human activities and free us from fossil fuels, and we need to implement this urgently.

The UN has declared 2008 the year of the Global Food Crisis, and it has been the top news story everyday for months now as the crisis deepens. Food prices increased by an average of 40 percent last year; a string of food riots and protests spread around the world including the UK, and more than 25 000 farmers killed themselves in India.

Most commentators agree that the immediate cause of the food crisis is the divestment of food grains into producing biofuels. BusinessWeek identified Monsanto as a “prime beneficiary”. Its stock correlated closely with the price of oil (better than ExxonMobile), and hardly correlated with the price of corn, basically because no one will eat its GM corn. Nevertheless the pro-GM lobby are out in force, using the food crisis to promote GM crops.

GM crops are one big failed experiment based on an obsolete scientific theory, and this failure has been evident since 2004 if not before [58] (Puncturing the GM Myths, SiS 22). Apart from yielding less and requiring more pesticides, anecdotal evidence since 2005 from farmers around the world indicates that GM crops also require more water [59]. Industrial Green Revolution agriculture is now generally acknowledged to be a major driver of climate change as well as being vulnerable to climate change because of its heavy dependence on fossil energies and water, and its susceptibility to pests, diseases and climate extremes [56, 60, 61] (Beware the New "Doubly Green Revolution", SiS 37)..GM crops have all the worst features of industrial Green Revolution varieties exaggerated, and not least, there are outstanding safety concerns as I mentioned. Growing GM crops for biofuels does not make them safe, as they will contaminate our food crops all the same.

Any further indulgence in GMOs will surely damage our chances of surviving global warming. We must get on with the urgent business of building organic, sustainable food and energy systems right now.

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