ISIS Report 15/10/2014
Genetic Modification Trails Conventional Breeding By Far
have created conventionally bred varieties tolerant to drought and low nitrogen
soils that can reduce poverty in 13 African countries by up to 9 %, far
outperforming anything that genetic modification has achieved Prof Peter Saunders
the debate about genetically modified (GM) crops, the argument that the biotech
industry and their supporters always fall back on is that whether we like it or
not, we are going to need them to feed the world. Genetic modification has,
they assure us, the potential to produce crops with all sorts of wonderful
traits: tolerance of drought, cold, salinity and flooding, resistance to insect
pests, extra nutritional value, and more.
But for the last 20 years, GM has singularly failed to
convert that potential into reality. Almost all the GM crops grown have been
modified to have one of two traits: tolerance of glyphosate-based herbicides
and the ability to produce a Bt-toxin that can kill corn- and cotton pests. In
the meantime, conventional breeding, often employing modern techniques such as
marker-assisted breeding, has continued to deliver the goods.
An article in a recent issue of the journal Nature
provides a striking example . GM and non-GM methods have both been applied
to developing improved varieties of maize, a crop of very great importance in
many countries. Non-GM has won hands down. If our real goal is to feed the
world, we should be taking resources away from GM and devoting them to other
agricultural research that is less glamorous-sounding but more effective.
breeding far outperforming genetic modification behind the biotech PR machine
originated in the New World, in or near Mexico and is still the most widely grown
grain in the Americas, but has spread across the globe. It is now the most
important staple crop in Africa.
Maize is susceptible to drought, a serious defect in a
crop on which so many people depend, especially as climate change is making
droughts more frequent. It does not thrive in soils that are poor in nitrogen,
again a problem for a crop widely cultivated by subsistence farmers. A great
deal of research is being devoted to overcoming these drawbacks, and improved
varieties are beginning to appear. Researchers are using both conventional
breeding and genetic modification (GM); though where GM is involved, it is used
together with conventional breeding because GM alone cannot do the job.
So far, conventional breeding has been a lot more
successful . That probably explains why you probably haven’t heard very much
about these achievements. Transferring a gene is still considered news,
especially with the public relations departments of the biotech industry.
new tolerant varieties can reduce hunger in Africa by up to 9 %
Drought Tolerant Maize for Africa Project has developed 153 new varieties. In
field trials, these have performed at least as well as existing commercial
seeds when the rainfall is adequate, and yielded up to 30% more during drought.
It is estimated that it will help reduce the number of people living in poverty
in 13 African countries by as much as 9 % .
The researchers who bred the new varieties were able to
draw on collections in a large seed bank run by the International Maize and
Wheat Improvement Center (CIMMYT) in Mexico City. Some of the varieties kept
there were known to thrive in dry regions, and these were first cross-bred to
produce varieties that were drought tolerant and then crossed with varieties
that are already successful in Africa.
new varieties that yield up to 1 tonne per hectare more in low nitrogen soils
at CIMMYT have also been participating in the Improved Maize for African Soils
(IMAS) project, along with the Kenya Agricultural Research Institute, the South
African Agricultural Research Council and DuPont Pioneer. So far, IMAS has
developed 21 conventionally bred varieties, which have yielded up to 1 tonne
per hectare more in nitrogen-poor soils than existing commercial varieties.
They hope to introduce these in eight countries over the next year.
IMAS is also working to develop GM varieties, but they
say these are at least 10 years from success. Biswanath Das, a maize researcher
at CIMMYT, is quoted in the journal Nature as saying that while “it is
important to consider all options,” conventional breeding will probably have a
greater impact .
It is not at all surprising that these crucial advances
have been achieved by conventional breeding rather than genetic engineering. Supporters
of GM like to give the impression that theirs is a very precise and quick
technology. You identify a gene for a desired trait, such as the ability to
produce Bt-toxin, you take it from the organism that has it (in this case the
soil bacterium Bacillus thuringensis), insert it into the DNA of the
organism you are interested in (in this case cotton or maize) and there you
are. In fact, it’s never as simple as that (see FAQ on Genetic Engineering , ISIS
Tutorial) and in a report from the strongly pro-GM International Service for
the Acquisition of Agri-biotech Applications (ISAAA)  we are told that it
generally takes about ten times more money and ten years longer to bring a
biotech crop to market compared to a conventional crop and also that this
“precludes the participation of public research institutions in the development
of biotech crops.”
The technology is uncontrollable and unpredictable,
introducing many unintended effects that are potentially unsafe, despite many
attempts at targeting the genetic modification precisely. We have compiled a
comprehensive report on the health and environmental hazards of genetically
modified organisms (GMOs), recommending individuals and local communities
everywhere to take action to  Ban GMOs Now (ISIS Special
Another big problem is that the majority of the traits
of any organism are determined not by a single gene but by interactions among
large number of genes. So transferring one stretch of DNA is unlikely to
needs help from conventional breeding plus some sleight of hand
Monsanto is not trying to produce drought tolerant maize genetic modification
alone. Instead, they are using conventional breeding but with a single transgene,
CspB, which they refer to as the “drought gene”, as if it were the only factor
that made a difference .
If conventional breeding has produced maize varieties
that can tolerate drought or produce higher yields in poor soil, why is there
still so much research into GM? Especially as the GM varieties involve a lot of
conventional breeding with perhaps a single artificially transferred gene?
One reason is of course that maize is such an important
crop that we don’t want to miss any possibility of improving it. It might just
be that genetic engineering will accomplish something important that cannot be
done by conventional breeding, though both our understanding of crops and our
experience so far strongly suggest that it will not. Another reason is that
many scientists have built up laboratories to do genetic engineering and they
are looking for something they can do with it. For them, GM is the answer even
before you tell them what the question is.
GM crops do, however, have one clear advantage: they
are patentable. Varieties that are produced by conventional breeding are
subject to breeders’ rights, which essentially limit what others can do with
them for commercial purposes. In contrast, varieties that are produced by
genetic modification can be patented, which means they are completely
controlled by the person or corporation that holds the patent. Farmers who buy
the seeds are actually not buying them in the sense that they are now theirs to
use as they please. All they have acquired is the right to grow a single crop
from the seeds. They cannot save the seeds from the crop to sow the next year
and neither the farmers nor anyone else are allowed to do research on them or
breed from them. The farmers cannot even give them to anyone. They have really
only rented the seeds, which remain the property of the company.
Hence even if a variety has been largely conventionally
bred, there is a very strong incentive for a corporation to include at least
one gene transferred by genetic engineering. That makes the variety patentable,
it gives it much stronger protection than are available under breeders’ rights,
and prevents anyone else from trying to improve it. What is more, if some other
gene can be transferred during the lifetime of the patent, the monopoly can be
extended indefinitely, in much the same way that a pharmaceutical company can
extend the patent on a drug by evergreening, i.e. making and patenting a
number of minor modifications (End of
Drug Monopolies and Mega-profits? SiS 58 )
To refer to CspB as the drought gene is more than just
a bit of marketing. It is also part of making the legal (as opposed to
scientific) case that it is the transgene that is responsible for the drought
tolerance of the variety, thus heading off any challenge to the patent. This
also explains why in their publicity Monsanto compare the conventionally bred
hybrid only with the variety that also contains CspB, not with the currently
available varieties they started with.
Six years ago, the editor of Nature Biotechnology
acknowledged in an editorial that GM crops were not addressing the key
agricultural problems. He wrote  that he was “not downbeat on its prospects
to, one day, heal, fuel and feed the world,” but admitted that was “an
outrageous act of faith, bordering on the religious.”
Since then, new varieties of maize, rice, cassava and
sweet potato have been developed that do address the problems that beset the world’s
food supply (How
Non-GM Cassava Can Help Feed the World SiS 59 ). Almost all have
been developed by conventional breeding, often with the help of marker assisted
breeding. Methods such as “push-pull” have been introduced to control insect
pests and weeds without the use of chemicals .
There are many reasons why we should be opposed to GM
crops. They bring with them all sorts of hazards, they lead to an increased use
of chemicals, they promote the development of superweeds and toxin-resistant insects, they court disaster by leaving the world with only
a very few varieties of each crop, and they enable a small number of
corporations to gain control of the world’s food supply. They are yet
another part of the campaign by the major seed companies to pressure
governments in developing countries to introduce laws that prevent farmers from
saving, replanting, exchanging and selling seeds, as they have done for
millennia and on which their livelihoods and their countries’ food security
All that might conceivably be worth risking if we actually
needed GM crops, but the plain fact is that we don’t.
N. Cross-bred crops get fit faster. Nature 2014, 513, 292. doi:10.1038/513292a.
2. La Rovere R, Abdoulaye T, Kostandini G, Guo Z, Mwangi W, MacRobert J,
Dixon J. 2014. Economic, Production and Poverty Impacts of Investing in Maize
Tolerant to Drought in Africa: An Ex ante Assessment. Journal of Developing
Areas 2014, 48, 199-225.
3. Ho MW.
FAQ on genetic engineering. ISIS Tutorial, 1999, http://www.i-sis.org.uk/FAQ.php
Service for the Acquisition of Agri-biotech Applications. Global Status of
Commercialized Biotech/GM Crops 2010. ISAAA, 2011. http://www.agbioworld.org/newsletter_wm/index.php?caseid=archive&newsid=3048
5. Ho MW
and Sirinathsinghji E. Ban GMOs Now, ISIS Special Report, June 2013,
6. Padgette S, Goette J and Mazour C. Drought-tolerant corn. http://www.monsanto.com/sitecollectiondocuments/whistlestop-drought-posters.pdf
7. Saunders PT. End of drug monopolies and megaprofits? Science in Society 58 2-4,
8. Marshall A. Join the dots. Nature Biotechnology 2008, 26,
9. Saunders PT. How non-GM cassava can help feed the world. Science in Society 59,
A, Herren H, Khan ZR, Pickett JA and Woodstock CM. Integrated pest
management: the push–pull approach for controlling insect pests and weeds of
cereals, and its potential for other agricultural systems including animal
husbandry. Philosophical Transactions of the Royal Society B
2008, 363, 611-621. doi:10.1098/rstb.2007.2173
T, Meienberg F, Pionetti C and Shashikant S. Owning Seeds, Accessing Food: A
Human Rights Impact Assessment of UPOV 1991 Based on Case Studies in Kenya,
Peru and the Philippines. The Berne Declaration, Zürich, 2014. http://www.evb.ch/fileadmin/files/documents/Saatgut/2014_07_10_Owning_Seed_-_Accessing_Food_report_def.pdf 15/10/14
There are 1 comments on this article so far. Add your comment
|Douglas Hinds Comment left 12th November 2014 09:09:25|
"GM crops do, however, have one clear advantage: they are patentable"
No other incentive exists for creating GM crops. Productivity, costs, environmental and public health benefits are all absent.
What this means is that capitalism is incompatible with evolutionary progress and an economic system based on principles similar to those driving the free software movement (i.e. the GPL), represents the only sustainable future available to mankind and the planet.