Wireless Phone Use Increases Malignant Brain Tumour Up to Four-Fold
Frequent use of mobile and cordless phone link to malignant brain
tumour confirmed in new comprehensive analysis based on the largest number of
cases in Sweden; 3G phones more damaging than 2G, and children more at risk;
“current guidelines for exposure should be urgently revised” Dr Mae-Wan Ho
The latest analysis includes pooled data from two case-control
studies of malignant brain tumours in Sweden diagnosed during 1997-2003 and
2007-2009 compared with controls matched on age and gender. Mobile phone use
increased the risk of glioma (the most common form of malignant brain tumour)
up to 3 fold with a latency period of > 25 years from first exposure.
Cordless phone use increased the risk of glioma up to 1.4 fold in the >15-25
year latency group. The highest risks were found for tumours on the same side
of the brain that the phone is used and on the temporal lobe next to the phone
. In addition, 3G phones appear more damaging in increasing the risk more
than 4-fold with latency period >5-10 years. And people who began using
mobile phones before the age of 20 are at higher risk than older age groups.
These findings do not come as a surprise. They confirm
a string of previous studies (see  Wireless
Phones and Brain Cancer and other articles in the series, SiS 51).
The principal investigator Lennart Hardell, a professor of oncology at
University of Örebro in Sweden first warned of the link between mobile phones
and brain tumours in a paper published in 1999
The new analysis
The new analysis, carried out by Hardell and statistician Michael
Carlberg in the same University department, includes data from two case-control
studies on patients diagnosed with malignant brain tumours in Sweden during
1997-2003 and 2007-2009 aged 20-80 years and 18-75 year respectively at the
time of diagnosis . Controls were matched on age and gender. Exposures to
emissions from phones were assessed by questionnaire. Special questions covered
the extent of use in a car with an external antenna and hands-free device, both
regarded as non-exposure. Also noted was the ear used most during phone
calls, or equally both ears. The participation rates were high with a total of 1
498 (89%) cases and 3 530 (87%) controls.
The case control studies covered periods during which
phone technologies had changed considerably. It started with first generation analogue
phones that had an output power of 1 W at about 900 MHz. The 2nd generation GSM
(Global System for Mobile Communication) phones (2G) with either 900 or 1800
MHz frequency had pulsed output power averaging tens of mW. The 3rd generation
(3G) phones UMTS (Universal Mobile Telecommunication System) are more amplitude
modulated than pulsed, and typically use a broad frequency band (5 MHz width) from
700-3 590 MHz on a worldwide basis, and from 900-2 170 MHz in Europe  with
output power of the order of tens of μW.
The main findings
The entire set of data was used in the regression analysis adjusted
for gender, age, year of diagnosis and socioeconomic index. The risk was
assessed as odds ratio (OR), which represents the odds that an outcome will
occur with a particular exposure compared to the odds of the outcome occurring
in the absence of that exposure.
The most common form of brain tumour in the patients (92
%) was glioma, a malignant tumour of the glial cells. Mobile phone use increased
the risk of glioma with OR 1.3 and 95% CI (confidence interval) 1.1-1.6
overall, increasing to OR 3.0, 95% CI 1.7-5.2 in the > 25 year latency
group. Use of cordless phones increased the risk to OR 1.4, 95% CI 1.1-1.7,
with highest risk in the >15-20 year latency group: OR 1.7, 95% CI 1.1-2.5.
The median latency time for diagnosis of glioma in use
of mobile phones was 9.0 years (mean 10.1, range 2-28). The corresponding
results for cordless phones were median 7.0 years (mean 8.0, range 2-21).
Analogue phones gave OR 1.6, 95% CI 1.2-2.0, increasing to OR 4.8, 95% CI
2.5-9.1 in the latency group of >25 years.
Proximity to phone radiation
For all phone types, ipsilateral use (glioma on same side of phone
use) had the highest risk, with OR 1.8, 95% CI 1.4-2.2, whereas contralateral
use gave OR 1.1, 95% CI 0.8-1.4. For cordless phones similarly, ipsilateral use
gave OR 1.7, 95% CI 1.3-2.1 compared with contralateral use OR 1.2, 95% CI
0.9-1.6. For mobile phones, the highest risk was associated with ipsilateral
use in the >25 year latency group, OR 4.6, 95% CI2.1-10. Contralateral
mobile phone use also gave a statistically significant increased risk in the
longest latency group, although with a lower OR than for ipsilateral use. Higher
ORs were found for ipsilateral cordless phone use in the different latency groups,
except for latency >20-25 years that were based on small numbers with wide
Still higher risks were found for glioma in the temporal
or overlapping lobes (n=505). Mobile phone use yielded OR 3.6, 95% CI 1.8-7.4 versus
OR 3.0, 95% CI 1.7-5.2 in total in the >25 years latency group. The
corresponding results for cordless phone in the >20-25 years latency group
were OR 2.1, 95% CI 0.6-7.0 versus OR 1.4, 95% CI 0.5-3.8, respectively. For glioma in the temporal lobe only (n=367), mobile phones gave OR
4.3, 95% CI 2.0-9.3 and cordless phones OR2.4, 95% CI 0.6-9.5.
Wireless phone use in total in the > 25 year latency
group gave OR3.7, 95% CI 1.8-7.4 for glioma in temporal or overlapping lobes, increasing
to OR 4.2, 95% CI 1.9-9.1 for glioma localised only in temporal
Youngest age group most at risk
The young are more vulnerable. The highest OR was obtained for first
use before the age of 20 years, OR 1.8, 95% CI 1.2-2.8, increasing for ipsilateral
use to OR 2.3, 95% CI 1.3-4.2. Cordless phone gave OR2.3, 95% CI 1.4-3.9 in
total for the age group < 20 years, increasing to OR 3.1, 95% CI 1.6-6.3 for
Risks go up with use
The group of total wireless phone use (mobile phone and/or cordless
phone) gave similar risks to mobile phone use, increasing with latency to
highest in the longest latency group of >25 years with OR 3.0, 95% CI
1.7-5.2.The risk increased per additional year of latency for wireless phones
was OR 1.032, 95% CI 1.019-1.046.
Risk also goes up per 100 h cumulative use for all
phone types; wireless phones as a group gave OR 1.011, 95 % CI 1.008-1.014.
3G more damaging than 2G
Digital 2G phones gave overall OR 1.3, 95% CI 1.1-1.6 increasing to
OR 2.1, 95% CI 1.5-3.0 with a latency >15-20 years, the longest latency
interval. For digital 3G phones, the highest risk was in the >5-10 years
latency group - the longest latency group as the technology is new - with OR
4.1, 95% CI 1.3-12, based on small numbers.
There is reason to suspect that 3G phones could be
more risky than 2G, even though the OR was based on short latency and rather
small number of subjects exposed. Contrary to 2G GSM, 3G UMTS emit wide-band
microwaves, which may result in greater biological effect.
There have been only two studies carried out by one
group of researchers comparing effects of 2G and 3G signals using the same
experimental approach. The first study was carried out on human lymphocytes
from 5 electrosensitive and 5 normal subjects . For 2G phones, effects on
human lymphocytes were specific to carrier frequency, with 915 MHz consistently
inhibiting DNA double strand break (DSB) repair in all subjects as (measured by
the marker protein 53BP1 locating to the breaks on chromosomes), whereas 905
MHz exposure had no effect. For UMTS 3G exposure at 1947.4 MHz, inhibition of
DSB repair was evident in cells from all subjects. There was no difference
between electrosensitive and normal subjects. The effects of 1 h exposure
lasted for 72 hours.
In the second study, human mesenchymal stem cells (MSCs)
is0lated from adipose tissue as well as normal human fibroblasts were used.
Again, GSM 915 MHz and UMTS 1947.4 MHz exposure reduced DNA DS break repair in
both cells lines, whereas GSM 905 Mhz exposure had no effect on fibroblasts,
but had some effect on MSCs . The level of reduction in MSCs was more pronounced
than in fibroblasts. The team tested whether MSCs and fibroblasts can adapt to
microwave effects during chronic exposure by exposing the cells for 2 weeks (5
days/week, 1h/day). The MSCs failed to adapt as DSB repair dropped almost to
zero, while the fibroblasts adapted and recovered its normal rate. Thus, the
strongest microwave effects were always observed in stem cells, which reacted to
a broader range of frequencies. And stem cells are increasingly thought to be
targets for origination of cancers including glioma.
The new study is the most comprehensive and reliable analysis done
on the largest number of subjects from a country that has the longest history
of mobile phone use, and confirm results of previous studies carried out by the
same research group since the late 1990s.
The International Agency on Research on Cancer (IARC)
at WHO (World Health Organization) evaluated human cancer risks from RF-EMF
(radio frequency electromagnetic field) exposure in May 2011 . It included
all sources in the frequency range of 30 kHz to 300 GHz. A total of 29 invited
scientists participated; the final classification of RF-EMF was Group 2B,
‘possibly’ a human carcinogen.
The evaluation on the long-term use of wireless phones,
i.e. >10 years, were
based on the results of Hardell’s group as well as the Interphone Study
. The tumours associated with the use of wireless phones are the malignant
types, mostly glioma, and acoustic neuroma, a benign tumour of the 8th cranial
nerve. In contrast, no consistent association was found for the most common
benign brain tumour, meningioma. The Interphone results reported only on the use
of mobile phones, and did not include cordless phones, that and other
methodological limitations serve to under-represent the risks involved .
The IARC evaluation was based on a fairly short latency
period, at most >10 years. The present study has greatly extended the
latency period and hence revealed the true extent of cancer risks from wireless
phone. The authors concluded that the emissions from mobile phones should be
 “regarded as carcinogenic, under Group 1 according to the IARC
classification, indicating that current guidelines for exposure should be
urgently revised.” The current guidelines are based on thermal effects – those
associated with increase in temperature in the exposed cells or tissues – based
on an equilibrium thermodynamics paradigm that applies to dead matter. Instead
organisms are non-equilibrium quantum coherent systems that depend on exquisite
sensitivity to ultraweak electromagnetic fields for intercommunication and
survival (see  Quantum
Coherent Water, Non-thermal EMF Effects, and Homeopathy, SiS 51).
There is now abundant evidence for such non-thermal effects of electromagnetic
fields, highlighted by the European Environment Agency in 2011 (see  European
Environment Agency Highlight Mobile Phone Cancer Risks, SiS 51).
Hardell L, Näsman Å, Påhlson A,
Hallquist A, Hansson Mild K, Use of cellular telephones and the risk for brain tumours: a case-control
study. International Journal of Oncology 1999, 15,113-6.
UMTS frequency bands. Wikipedia, 15 September 2014,
Belyaev IY, Marková E, Malmgren LOG and Persson BRR. Microwaves
from UMTS/GSM induce long-lasting inhibition of 53BP1/g-H2AX repair foci
in human lymphocytes. Bioelectromagnetics 2009, 30, 129-41.
Marková E, Malmgren LOG and Belyaev IY. Microwaves from mobile
phones inhibit 53BP1 focus formation in human stem cells more strongly
than in differentiated cells: possible mechanistic link to cancer risk. Environ
Health Persp 2010, 118, 394-9.
Joan of Arc Comment left 12th November 2014 23:11:10 This is disturbing on so many different levels. As a parent, I have been shielding my child from cell phone because of the concern for brain tumors and little studies on the effects of teh signal on teh developing brain, with little consideration for the no ubiquitous wifi and now RF radiation coming from all these smart meters/ appliances.
And I thought 30 years of non-labeled GMO's were bad...
Alison Comment left 13th November 2014 08:08:24 I deeply appreciate more studies being published. The independent scientists are describing this overexposure of electromagnetic radiation as the BIGGEST health crisis the planet and its inhabitants have ever faced. See what the experts are saying at http://EMFsummit.com
Brigitte Hansmann Comment left 13th November 2014 18:06:20 It is very disturbing. And there is more: I recently saw images of red blood cells of healthy individuals who had been asked to abstain from using their cell phone for a certain amount of time. I can't remember whether it was a few hours of days. The red blood cell were evenly distributed in the blood with a beautiful light surrounding them. After four hours of carrying a cell phone in a backpack, without using it, the blood cells began sticking together, and after, I believe it was 30 minutes of using the cell phone, they had aggregated in coin rolls. Is that scary or what?
Barry Carter Comment left 14th November 2014 22:10:23 There is some emerging evidence that the ormus nutrients are converted to their toxic metal counterparts by EMF exposure. These nutrients my also be responsible for quantum coherence between biological cells. They exhibit quantum properties at biological temperatures. They have also been associated with repair of damaged DNA.
Google ormus and coherence for more info and supporting data.